Bile Pigments: Newcomers to the Cell Signaling Arena
نویسندگان
چکیده
منابع مشابه
Bile pigments: newcomers to the cell signaling arena.
The article highlighted in this issue is "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Accumulation of Biliverdin and Hepatic Peliosis in Rats," by Marjo Nittynen, Jouni T. Tuomisto, Seppo Auriola, Raimo Pohjanvirta, Paula Syrjälä, Ulla Simanainen, Matti Viluksela, and Jouko Tuomisto (pp. 112-123).
متن کاملThe Role of Bile Pigments in Health and Disease: Effects on Cell Signaling, Cytotoxicity, and Cytoprotection
of neointima formation and reduction of vascular smooth muscle cell proliferation and migration (Peyton et al., 2012). In microvascular endothelial cells, low (“physiological”) bilirubin concentrations induce apoptosis, which is exacerbated under hyperglycemic conditions. Endothelial cells of the blood-brain barrier are particularly sensitive to these effects of bilirubin (Kapitulnik et al., 20...
متن کاملOrigin of Bile Pigments
S. H. ROBINSON (Boston) described a new experimental technique for studying the early labelled component of bilirubin in the ligated bile duct of the Gunn rat. Using 14C bilirubin he measured the total miscible bilirubin pool. In addition, the rate of bile pigment formation following the administration of 2-14C glycine was estimated. This allowed precise assessment of bilirubin and haem product...
متن کاملLv. Studies on Bile Pigments
THE study of bile pigment derivatives is important because these substances represent the end-products of haemoglobin metabolism. The destruction of haemoglobin both normal and pathological can thus be measured by quantitative determination of the urobilin and urobilinogen in urine and faeces. On the other hand, when pathological destruction of haemoglobin can be excluded, urobilinor urobilinog...
متن کاملThe Enzymatic Degradation of Hemoglobin to Bile Pigments by Macrophages
Recent studies have identified and characterized the enzymatic mechanism by which hemoglobin-heme is converted to bilirubin. Under physiologic conditions the enzyme system, microsomal heme-oxygenase, is most active in the spleen followed by the liver and bone marrow, all of which are tissues that normally are involved in the sequestration and metabolism of red cells. Indirect evidence suggested...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2003
ISSN: 1096-0929
DOI: 10.1093/toxsci/71.1.9